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Title: Novel series of [ddN]-[TSAO-T] heterodimers as potential bi-functional inhibitors of HIV-1 RT. Studies in the linker and ddN region
Authors: Velázquez, S ×
Tuñón, V
Jimeno, M L
Pérez-Pérez, M J
San-Félix, A
Chamorro, C
Lobatón, E
Esteban-Gamboa, A
De Clercq, Erik
Balzarini, Jan
Camarasa, M J #
Issue Date: 26-Aug-1999
Host Document: Nucleosides & nucleotides vol:18 issue:4-5 pages:1029-30
Conference: XIIIth International Round Table of Nucleosides, Nucleotides, and their Biological Applications location:Montpellier, France date:6-10 September 1998
Abstract: Novel series of [ddN]-(CH2)n-[TSAO-T] heterodimers have been prepared and tested for their anti-HIV-1 and HIV-2 activity. The most active compound of this series was the [d4T]-(CH2)3-[TSAO-T] heterodimer (EC50 = 0.018 +/- 0.03 microM).
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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