Title: Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5'-phosphoramidates and 5'-diphosphates, of 2'-O-allyl-arabinofuranosyl nucleosides
Authors: Manfredini, S ×
Baraldi, P G
Durini, E
Balzarini, Jan
De Clercq, Erik
Karlsson, A
Buzzoni, V
Thelander, L #
Issue Date: 26-Aug-1999
Publisher: M. Dekker
Series Title: Nucleosides & Nucleotides vol:18 issue:4-5 pages:1007-1008
Conference: XIIIth International Round Table of Nucleosides, Nucleotides, and their Biological Applications location:Montpellier, France date:6-10 September 1998
Abstract: The diphosphates of a series of 2'-O-allyl-1-beta-D-arabinofuranosyl derivatives, previously obtained by us, have been prepared and tested for their inhibitory activity in an in vitro assay using R1 and R2 subunits of the purified recombinant mouse ribonucleotide reductase (RNR). 2'-O-Allyl-araU diphosphate proved to be inhibitory, with an IC50 of 100 microM. The 5'-phosphoramidate pronucleotide of 2'-O-allyl-araU was also prepared and tested for inhibition of tumor cell proliferation.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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