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Title: Prodrugs of Ara-CMP and Ara-AMP with a S-acyl-2-thioethyl (SATE) biolabile phosphate protecting group: synthesis and biological evaluation
Authors: Bazzanini, R ×
Manfredini, S
Durini, E
Gröschel, B
Cinatl, J
Balzarini, Jan
De Clercq, Erik
Imbach, J L
Périgaud, C
Gosselin, G #
Issue Date: 26-Aug-1999
Host Document: Nucleosides & nucleotides vol:18 issue:4-5 pages:971-2
Conference: XIIIth International Round Table of Nucleosides, Nucleotides, and their Biological Applications location:Montpellier, France date:6-10 September 1998
Abstract: The bis(S-pivaloyl-2-thioethyl) phosphotriesters of Ara-C and Ara-A were synthesized as potential bioreversible mononucleotide prodrugs. Some N- and O-acylated derivatives were also prepared with the aim to modify the lipophilicity of the title pronucleotides. Compounds were tested for their antitumor/antiviral activity against a variety of tumor cells and viruses.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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