Title: An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs
Authors: Ballatore, C ×
McGuigan, C
De Clercq, Erik
Balzarini, Jan #
Issue Date: 26-Aug-1999
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:18 issue:4-5 pages:967-969
Conference: XIIIth International Round Table of Nucleosides, Nucleotides, and their Biological Applications location:Montpellier, France date:6-10 September 1998
Abstract: The pig liver esterase (PLE) assay has been designed to "reproduce" in vitro the first step of the metabolism of phosphoramidate pro-drugs that generates the free amino acyl phosphoramidate intermediate which has been described as a key metabolite necessary but not sufficient for the biological activity. The method could be used as a predictive tool for the likely in vitro biological activity as well as for Structure-Activity Relationship establishment (SAR).
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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