Title: Novel TSAO derivatives modified at positions 3" and 4" of the spiro moiety
Authors: Lobatón, E ×
Velázquez, S
San-Félix, A
Chamorro, C
Tuñón, V
Esteban-Gamboa, A
De Clercq, Erik
Balzarini, Jan
Camarasa, M J
Pérez-Pérez, M J #
Issue Date: 26-Aug-1999
Host Document: Nucleosides & nucleotides vol:18 issue:4-5 pages:675-6
Conference: XIIIth International Round Table of Nucleosides, Nucleotides, and their Biological Applications location:Montpellier, France date:6-10 September 1998
Abstract: We have explored the introduction of different functional groups at positions 3" and 4" of the spiro moiety of TSAO-T. Alkylation of this spiro moiety afforded mixtures of N and/or C-alkylated derivatives, while acylation occurs, exclusively, on the amino group. Position 3" has been selectively functionalized by halogenation followed by Stille-cross coupling reaction with organostannanes under a variety of experimental conditions.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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