Title: BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks
Authors: Beets, Karen ×
Staring, Michael
Criem, Nathan
Maas, Elke
Schellinx, Niels
de Sousa Lopes, Susana M Chuva
Umans, Lieve
Zwijsen, An #
Issue Date: Oct-2016
Publisher: BioMed Central
Series Title: BMC Developmental Biology vol:16 issue:1 pages:1-16
Abstract: Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output in endothelial cells is highly context- and dose-dependent. Phosphorylation of the BMP intracellular effectors, SMAD1/5/9, is routinely used to monitor BMP signalling activity. To better understand the in vivo context-dependency of BMP-SMAD signalling, we investigated differences in BMP-SMAD transcriptional activity in different vascular beds during mouse embryonic and postnatal stages. For this, we used the BRE::gfp BMP signalling reporter mouse in which the BMP response element (BRE) from the ID1-promotor, a SMAD1/5/9 target gene, drives the expression of GFP.
ISSN: 1471-213X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Developmental Signaling (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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