Title: Biosafety standards for working with Crimean-Congo haemorrhagic fever virus
Authors: Weidmann, Manfred ×
Avsic-Zupanc, Tatjana
Bino, Silvia
Bouloy, Michelle
Burt, Felicity
Chinikar, Sadegh
Christova, Iva
Dedushaj, Isuf
El-Sanousi, Ahmed
Elaldi, Nazif
Hewson, Roger
Hufert, Frank T
Humolli, Isme
Jansen van Vuren, Petrus
Koçak Tufan, Zeliha
Korukluoglu, Gülay
Lyssen, Pieter
Mirazimi, Ali
Neyts, Johan
Niedrig, Matthias
Ozkul, Aykut
Papa, Anna
Paweska, Janusz
Sall, Amadou A
Schmaljohn, Connie S
Swanepoel, Robert
Uyar, Yavuz
Weber, Friedemann
Zeller, Herve #
Issue Date: Sep-2016
Publisher: Society for General Microbiology
Series Title: Journal of General Virology vol:Ahead of print
Article number: 10.1099/jgv.0.000610
Abstract: In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus CCHF virus (CCHFV) is classified as a hazard group 4 agent and handled in containment level 4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL) -2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the required tests to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the affected countries. Downgrading of CCHFV research work from Cl-4, BSL-4 to Cl-3, BSL-3 should also be considered.
ISSN: 0022-1317
Publication status: accepted
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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