Fransolet, Gilles × Ehx, Grégory Somja, Joan Delens, Loïc Hannon, Muriel Muller, Joséphine Dubois, Sophie Drion, Pierre Caers, Jo Humblet-Baron, Stephanie Delvenne, Philippe Beguin, Yves Conteduca, Giuseppina Baron, Frédéric #
BioMed Central Ltd.
Journal of Hematology & Oncology vol:9 issue:1 pages:53-65
Previous studies have demonstrated that regulatory T cells (Tregs) play a protective role in the pathogenesis of chronic graft-versus-host disease (cGVHD). Tregs constitutively express the gene of the transcription factor Foxp3 whose CNS2 region is heavily methylated in conventional CD4(+) T cells (CD4(+)Tconvs) but demethylated in Tregs.