Inflammatory gene expression profile and defective IFN-γ and granzyme K in natural killer cells of systemic juvenile idiopathic arthritis patients

Put, Karen; Vandenhaute, Jessica; Avau, Anneleen; Van Nieuwenhuijze, Annemarie; Brisse, Ellen; Dierckx, Tim; Rutgeerts, Omer; Garcia-Perez, Josselyn; Toelen, Jaan; Waer, Mark; Leclercq, Georges; Goris, An; Van Weyenbergh, Johan; Liston, Adrian; De Somer, Lien; Wouters, Carine; Matthys, Patrick

doi:10.1002/art.39933

Inflammatory gene expression profile and defective IFN-γ and granzyme K in natural killer cells of systemic juvenile idiopathic arthritis patients

Author:

Put, Karen

Vandenhaute, Jessica ; Avau, Anneleen ; Van Nieuwenhuijze, Annemarie ; Brisse, Ellen ; Dierckx, Tim ; Rutgeerts, Omer ; Garcia-Perez, Josselyn ; Toelen, Jaan ; Waer, Mark ; Leclercq, Georges ; Goris, An ; Van Weyenbergh, Johan ; Liston, Adrian ; De Somer, Lien ; Wouters, Carine ; Matthys, Patrick

Keywords:

Science & Technology, Life Sciences & Biomedicine, Rheumatology, MACROPHAGE ACTIVATION SYNDROME, HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, RHEUMATOID-ARTHRITIS, PERIPHERAL-BLOOD, PATHOGENESIS, DYSFUNCTION, INTERLEUKIN-18, CYTOKINES, ANTAGONISTS, MUTATIONS, Arthritis, Juvenile, Cells, Cultured, Gene Expression, Granzymes, Humans, Interferon-gamma, Killer Cells, Natural, Phenotype, 3202 Clinical sciences, 3204 Immunology

Abstract:

Systemic juvenile idiopathic arthritis (sJIA) is an immune-inflammatory disease characterized by arthritis and systemic features. The role of natural killer (NK) cells in sJIA pathogenesis remains unclear. Therefore, we performed a comprehensive analysis of NK cell phenotype and functionality in sJIA patients.