Title: Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure
Authors: Clària, Joan ×
Stauber, Rudolf E
Coenraad, Minneke J
Moreau, Richard
Jalan, Rajiv
Pavesi, Marco
Amorós, Àlex
Titos, Esther
Alcaraz-Quiles, José
Oettl, Karl
Morales-Ruiz, Manuel
Angeli, Paolo
Domenicali, Marco
Alessandria, Carlo
Gerbes, Alexander
Wendon, Julia
Nevens, Frederik
Trebicka, Jonel
Laleman, Wim
Saliba, Faouzi
Welzel, Tania M
Albillos, Agustin
Gustot, Thierry
Benten, Daniel
Durand, François
Ginès, Pere
Bernardi, Mauro
Arroyo, Vicente #
Issue Date: Oct-2016
Publisher: W.B. Saunders
Series Title: Hepatology vol:64 issue:4
Article number: 10.1002/hep.28740
Abstract: Acute-on-chronic liver failure (ACLF) in cirrhosis is characterized by acute decompensation (AD), organ failure(s), and high short-term mortality. Recently, we have proposed (systemic inflammation [SI] hypothesis) that ACLF is the expression of an acute exacerbation of the SI already present in decompensated cirrhosis. This study was aimed at testing this hypothesis and included 522 patients with decompensated cirrhosis (237 with ACLF) and 40 healthy subjects. SI was assessed by measuring 29 cytokines and the redox state of circulating albumin (HNA2), a marker of systemic oxidative stress. Systemic circulatory dysfunction (SCD) was estimated by plasma renin (PRC) and copeptin (PCC) concentrations. Measurements were performed at enrollment (baseline) in all patients and sequentially during hospitalization in 255. The main findings of this study were: (1) Patients with AD without ACLF showed very high baseline levels of inflammatory cytokines, HNA2, PRC, and PCC. Patients with ACLF showed significantly higher levels of these markers than those without ACLF; (2) different cytokine profiles were identified according to the type of ACLF precipitating event (active alcoholism/acute alcoholic hepatitis, bacterial infection, and others); (3) severity of SI and frequency and severity of ACLF at enrollment were strongly associated. The course of SI and the course of ACLF (improvement, no change, or worsening) during hospitalization and short-term mortality were also strongly associated; and (4) the strength of association of ACLF with SI was higher than with SCD.
ISSN: 0270-9139
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
× corresponding author
# (joint) last author

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