Title: Novel highly divergent reassortant bat rotaviruses in Cameroon, without evidence of zoonosis
Authors: Yinda, Kwe Claude
Zeller, Mark
Conceição-Neto, Nádia
Maes, Piet
Deboutte, Ward
Beller, Leen
Heylen, Elisabeth
Ghogomu, Stephen Mbigha
Van Ranst, Marc
Matthijnssens, Jelle # ×
Issue Date: Sep-2016
Series Title: Scientific Reports vol:6
Article number: 10.1038/srep34209
Abstract: Bats are an important reservoir for zoonotic viruses. To date, only three RVA strains have been reported in bats in Kenya and China. In the current study we investigated the genetic diversity of RVAs in fecal samples from 87 straw-colored fruit bats living in close contact with humans in Cameroon using viral metagenomics. Five (near) complete RVA genomes were obtained. A single RVA strain showed a partial relationship with the Kenyan bat RVA strain, whereas the other strains were completely novel. Only the VP7 and VP4 genes showed significant variability, indicating the occurrence of frequent reassortment events. Comparing these bat RVA strains with currently used human RVA screening primers indicated that most of the novel VP7 and VP4 segments would not be detected in routine epidemiological screening studies. Therefore, novel consensus screening primers were developed and used to screen samples from infants with gastroenteritis living in close proximity with the studied bat population. Although RVA infections were identified in 36% of the infants, there was no evidence of zoonosis. This study identified multiple novel bat RVA strains, but further epidemiological studies in humans will have to assess if these viruses have the potential to cause gastroenteritis in humans.
ISSN: 2045-2322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of health and social work - UC Leuven
Laboratory of Virology and Chemotherapy (Rega Institute)
Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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