Title: PCR-based detection of Aspergillus fumigatus Cyp51A mutations on bronchoalveolar lavage: a multicentre validation of the AsperGenius assay® in 201 patients with haematological disease suspected for invasive aspergillosis
Authors: Chong, G M ×
van der Beek, M T
von dem Borne, P A
Boelens, J
Steel, E
Kampinga, G A
Span, L F R
Lagrou, Katrien
Maertens, J A
Dingemans, G J H
Gaajetaan, G R
van Tegelen, D W E
Cornelissen, J J
Vonk, A G
Rijnders, B J A #
Issue Date: Aug-2016
Publisher: Oxford University Press
Series Title: The Journal of Antimicrobial Chemotherapy vol:Ahead of print
Article number: dkw323
Abstract: In patients with invasive aspergillosis (IA), fungal cultures are mostly negative. Consequently, azole resistance often remains undetected. The AsperGenius(®) multiplex real-time PCR assay identifies clinically relevant Aspergillus species and four resistance-associated mutations (RAMs; TR34/L98H/T289A/Y121F) in the Cyp51A gene. This multicentre study evaluated the diagnostic performance of this assay on bronchoalveolar lavage (BAL) fluid and correlated the presence of RAMs with azole treatment failure and mortality.
ISSN: 0305-7453
Publication status: accepted
KU Leuven publication type: IT
Appears in Collections:Faculty of health and social work - UC Leuven
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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