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Title: Pneumocystis jirovecii pneumonia: still a concern in patients with haematological malignancies and stem cell transplant recipients
Authors: Cordonnier, Catherine ×
Cesaro, Simone
Maschmeyer, Georg
Einsele, Hermann
Donnelly, J Peter
Alanio, Alexandre
Hauser, Philippe M
Lagrou, Katrien
Melchers, Willem J G
Helweg-Larsen, Jannik
Matos, Olga
Bretagne, Stéphane
Maertens, Johan #
Issue Date: Sep-2016
Publisher: Oxford University Press
Series Title: The Journal of Antimicrobial Chemotherapy vol:71 issue:9 pages:2379-2385
Article number: 10.1093/jac/dkw155
Abstract: Pneumocystis jirovecii can cause life-threatening pneumonia following treatment for haematological malignancies or after HSCT. The mortality rate of P. jirovecii pneumonia (PCP) in these patients is 30%-60%, especially after HSCT. The clinical presentation of PCP in haematology differs from that associated with HIV infection, with the disease being acute and more often severe, having a lower fungal burden and being more frequently linked to treatment with corticosteroids. Most cases occur in patients not receiving adequate prophylaxis. The development of new therapies, including targeted treatments and monoclonal antibodies in various haematological diseases, justifies constant vigilance in order to identify new at-risk populations and give prophylaxis accordingly. The fifth and sixth European Conferences on Infections in Leukaemia (ECIL-5 and ECIL-6) aimed to review risk factors for PCP in haematology patients and to establish evidence-based recommendations for PCP diagnosis, prophylaxis and treatment. This article focuses on the magnitude of the problem, the main differences in clinical presentation between haematology patients and other immunocompromised populations, especially HIV-infected patients, and the main risk factors.
URI: 
ISSN: 0305-7453
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of health and social work - UC Leuven
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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