Title: ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients
Authors: Maertens, Johan ×
Cesaro, Simone
Maschmeyer, Georg
Einsele, Hermann
Donnelly, J Peter
Alanio, Alexandre
Hauser, Philippe M
Lagrou, Katrien
Melchers, Willem J G
Helweg-Larsen, Jannik
Matos, Olga
Bretagne, Stéphane
Cordonnier, Catherine #
Issue Date: Sep-2016
Publisher: Oxford University Press
Series Title: The Journal of Antimicrobial Chemotherapy vol:71 issue:9 pages:2397-2404
Article number: 10.1093/jac/dkw157
Abstract: The 5th European Conference on Infections in Leukaemia (ECIL-5) meeting aimed to establish evidence-based recommendations for the prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in non-HIV-infected patients with an underlying haematological condition, including allogeneic HSCT recipients. Recommendations were based on the grading system of the IDSA. Trimethoprim/sulfamethoxazole given 2-3 times weekly is the drug of choice for the primary prophylaxis of PCP in adults ( A-II: ) and children ( A-I: ) and should be given during the entire period at risk. Recent data indicate that children may benefit equally from a once-weekly regimen ( B-II: ). All other drugs, including pentamidine, atovaquone and dapsone, are considered second-line alternatives when trimethoprim/sulfamethoxazole is poorly tolerated or contraindicated. The main indications of PCP prophylaxis are ALL, allogeneic HSCT, treatment with alemtuzumab, fludarabine/cyclophosphamide/rituximab combinations, >4 weeks of treatment with corticosteroids and well-defined primary immune deficiencies in children. Additional indications are proposed depending on the treatment regimen.
ISSN: 0305-7453
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of health and social work - UC Leuven
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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