Title: Wheat bran components modulate intestinal bacteria and gene expression of barrier function relevant proteins in a piglet model
Authors: Chen, Hong ×
Chen, Daiwen
Qin, Wen
Liu, Yuntao
Che, Lianqiang
Huang, Zhiqing
Luo, Yuheng
Zhang, Qinghui
Lin, Derong
Liu, Yaowen
Han, Guoquan
Desmet, Stef
Michiels, Joris #
Issue Date: Aug-2016
Series Title: International Journal of Food Sciences and Nutrition vol:Ahead of print
Abstract: The objective of this study was to determine the impact of wheat bran and its main polysaccharides on intestinal bacteria and gene expression of intestinal barrier function relevant proteins. Thirty freshly weaned male piglets were assigned randomly to five dietary treatment groups with six piglets per group. Accordingly, five synthetic diets including a basal control diet without fiber components (CON), wheat bran diet (10% wheat bran, WB), arabinoxylan diet (AX), cellulose diet (CEL) and combined diet of arabinoxylan and cellulose (CB) were studied. The piglets were fed ad libitum for 30 d. Lower Escherichia coli (E. coli) populations in WB group and higher probiotic (Lactobacillus and Bifidobacterium) populations in groups fed diets containing arabinoxylan (WB, AX and CB) were observed and compared with CON group. Compared with CON group, the gene expressions of cystic fibrosis transmembrane conductance regulator (CFTR), calcium-activated chloride channel regulator 1 (CLCA1) and voltage-gated chloride channel 2 (CIC2) were suppressed in the WB group. And wheat bran down-regulated gene expression of pro-inflammation (TNF-α, IL-1β, IL-6) and TLRs/MyD88/NF-κB pathway compared with CON group. In conclusion, wheat bran and its main polysaccharides could change intestinal microflora and down-regulate the gene expression of intestinal barrier function relevant proteins in the distal small intestinal mucosa.
ISSN: 0963-7486
Publication status: accepted
KU Leuven publication type: IT
Appears in Collections:Computer Science Technology TC, Campus Group T Leuven
Hydraulics Section
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.