Tacrolimus-related polyneuropathy: case report and review of the literature
De Weerdt, Annick × Claeys, Kristl De Jonghe, Peter Ysebaert, Dirk Chapelle, Thiery Roeyen, Geert Jorens, Philippe G #
Clinical Neurology and Neurosurgery vol:110 issue:3 pages:291-294
Patients, in particular recipients of orthotopic liver transplants, receiving the immunosuppressant tacrolimus (FK-506), are at risk for developing central neurotoxic adverse events. We report the occurrence of a tacrolimus-induced peripheral neurotoxic event, i.e. pure motor axonal polyneuropathy of the lower limbs in a 44-year-old woman, 9 days after combined orthotopic liver and pancreas transplantation. She was treated for 5 days with intravenous immunoglobulins. Partial recovery followed over months to years. An overview of all 11 reported FK506-associated polyneuropathies is given.