European Journal of Neurology
Author:
Keywords:
Adult, Aged, Amyotrophic Lateral Sclerosis, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Disease Susceptibility, Erythromelalgia, Female, Humans, Male, Middle Aged, Polyneuropathies, Sphingolipids, Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, atypical sphingolipids, biomarker, 1-deoxySL, deoxysphingolipids, diabetic distal sensorimotor polyneuropathy, L-serine, polyneuropathy, type 2 diabetes mellitus, FAMILIAL AMYLOID POLYNEUROPATHY, DEOXYSPHINGOLIPIDS, METABOLISM, SEVERITY, CRITERIA, SUBUNIT, 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery, 3202 Clinical sciences, 3209 Neurosciences
Abstract:
Diabetic distal sensorimotor polyneuropathy (DSPN) is a frequent, disabling complication of diabetes mellitus. There is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM). Whether neurotoxic 1-deoxy-sphingolipids are elevated in DSPN patients' plasma and whether levels correlate to the DSPN stage were examined.