Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy?
Dohrn, M F Othman, A Hirshman, S K Bode, H Alecu, I Fähndrich, E Karges, W Weis, J Schulz, J B Hornemann, T Claeys, Kristl # ×
European Journal of Neurology vol:22 issue:5 pages:806-814
Diabetic distal sensorimotor polyneuropathy (DSPN) is a frequent, disabling complication of diabetes mellitus. There is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM). Whether neurotoxic 1-deoxy-sphingolipids are elevated in DSPN patients' plasma and whether levels correlate to the DSPN stage were examined.