ITEM METADATA RECORD
Title: Probing gamma-secretase-substrate interactions at the single amino acid residue level
Authors: Chavez Gutierrez, Lucia
De Strooper, Bart # ×
Issue Date: Jul-2016
Publisher: Nature Publishing Group
Series Title: EMBO Journal vol:35 issue:15 pages:1597-1599
Abstract: Intramembrane proteolysis by c-secretases
plays major roles in disease pathology
and cellular signalling, yet the
dynamics of these enzyme complexes and
how they recognize substrates remains
poorly understood. New work in The EMBO
Journal utilizes photo-affinity cross-linking
to map APP interactions to different
c-secretase subunits, suggesting a succession
of recruitment and engagement steps
that lead up to substrate cleavage.
ISSN: 0261-4189
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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