Title: Circulating 3-T1AM and 3,5-T2 in critically ill patients: a cross-sectional observational study
Authors: Langouche, Lies * ×
Lehmphul, Ina *
Vander Perre, Sarah
Koehrle, Josef
Van den Berghe, Greet #
Issue Date: Sep-2016
Publisher: Mary Ann Liebert Publishers
Series Title: Thyroid vol:Ahead of print
Abstract: Critical illness is hallmarked by low circulating T4 and T3 concentrations, in the presence of elevated rT3 and low-normal TSH, referred to as non-thyroidal illness (NTI). Thyroid hormone (TH) metabolism is substantially increased during NTI, in part explained by enhanced deiodinase 3 (D3) activity. T4- and T3-sulfate concentrations are elevated, due to suppressed D1 activity in the presence of unaltered sulfotransferase activity, and 3,3'-diiodothyronine (3,3'-T2) concentrations are normal. To further elucidate the driving forces behind increased TH metabolism during NTI, two other potential T4 metabolites, 3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM), were measured and related to their potential TH precursors.
ISSN: 1050-7256
Publication status: accepted
KU Leuven publication type: IT
Appears in Collections:Laboratory of Intensive Care Medicine
* (joint) first author
× corresponding author
# (joint) last author

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