Platinum-based chemotherapy induces methylation changes in blood DNA associated with overall survival in ovarian cancer patients
Flanagan, James M × Wilson, Angela Koo, Chail Masrour, Nahal Gallon, John Loomis, Erick Flower, Kirsty Wilhelm-Benartzi, Charlotte Hergovich, Alexander Cunnea, Paula Gabra, Hani Braicu, Elena I Sehouli, Jalid Darb-Esfahani, Silvia Vanderstichele, Adriaan Vergote, Ignace Kreuzinger, Caroline Cacsire Castillo-Tong, Dan Wisman, Gijsbertha Ba Berns, Els M J J Siddiqui, Nadeem Brown, Robert #
Association for Cancer Research
Clinical Cancer Research vol:Ahead of print
DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA methylating enzyme DNMT1, resulting in aberrant methylation. We hypothesised that DNA damage repair during platinum-based chemotherapy may cause aberrant DNA methylation in normal tissues of patients such as blood.