Title: Platinum-based chemotherapy induces methylation changes in blood DNA associated with overall survival in ovarian cancer patients
Authors: Flanagan, James M ×
Wilson, Angela
Koo, Chail
Masrour, Nahal
Gallon, John
Loomis, Erick
Flower, Kirsty
Wilhelm-Benartzi, Charlotte
Hergovich, Alexander
Cunnea, Paula
Gabra, Hani
Braicu, Elena I
Sehouli, Jalid
Darb-Esfahani, Silvia
Vanderstichele, Adriaan
Vergote, Ignace
Kreuzinger, Caroline
Cacsire Castillo-Tong, Dan
Wisman, Gijsbertha Ba
Berns, Els M J J
Siddiqui, Nadeem
Brown, Robert #
Issue Date: Sep-2016
Publisher: Association for Cancer Research
Series Title: Clinical Cancer Research vol:Ahead of print
Article number: clincanres.1754.2016
Abstract: DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA methylating enzyme DNMT1, resulting in aberrant methylation. We hypothesised that DNA damage repair during platinum-based chemotherapy may cause aberrant DNA methylation in normal tissues of patients such as blood.
ISSN: 1078-0432
Publication status: accepted
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
× corresponding author
# (joint) last author

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