Title: Establishing Biomarkers in Transplant Medicine: A Critical Review of Current Approaches
Authors: Anglicheau, Dany ×
Naesens, Maarten
Essig, Marie
Gwinner, Wilfried
Marquet, Pierre #
Issue Date: Oct-2016
Publisher: Lippincott Williams & Wilkins
Series Title: Transplantation vol:100 issue:10 pages:2024-2038
Article number: 10.1097/TP.0000000000001321
Abstract: Although the management of kidney transplant recipients has greatly improved over recent decades, the assessment of individual risks remains highly imperfect. Individualized strategies are necessary to recognize and prevent immune complications early and to fine-tune immunosuppression, with the overall goal to improve patient and graft outcomes. This review discusses current biomarkers and their limitations, and recent advancements in the field of noninvasive biomarker discovery. A wealth of noninvasive monitoring tools has been suggested that use easily accessible biological fluids such as urine and blood, allowing frequent and sequential assessments of recipient's immune status. This includes functional cell-based assays and the evaluation of molecular expression on a wide spectrum of platforms. Nevertheless, the translation and validation of exploratory findings and their implementation into standard clinical practice remain challenging. This requires dedicated prospective interventional trials demonstrating that the use of these biomarkers avoids invasive procedures and improves patient or transplant outcomes.
ISSN: 0041-1337
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
× corresponding author
# (joint) last author

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