Title: Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes
Authors: Dufour, Audrey
Seibt, Julie
Passante, Lara
Depaepe, Vanessa
Ciossek, Thomas
Frisén, Jonas
Kullander, Klas
Flanagan, John G
Polleux, Franck
Vanderhaeghen, Pierre # ×
Issue Date: Jul-2003
Publisher: Cell Press
Series Title: Neuron vol:39 issue:3 pages:453-465
Abstract: The mechanisms generating precise connections between specific thalamic nuclei and cortical areas remain poorly understood. Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic mapping of thalamocortical (TC) axons. In addition, we show that the same ephrin/Eph genes unexpectedly control the inter-areal specificity of TC projections through the early topographic sorting of TC axons in an intermediate target, the ventral telencephalon. Our results constitute the first identification of guidance cues involved in inter-areal specificity of TC projections and demonstrate that the same set of mapping labels is used differentially for the generation of topographic specificity of TC projections between and within individual cortical areas.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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