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Title: An intrinsic mechanism of corticogenesis from embryonic stem cells
Authors: Gaspard, Nicolas
Bouschet, Tristan
Hourez, Raphael
Dimidschstein, Jordane
Naeije, Gilles
van den Ameele, Jelle
Espuny-Camacho, Ira
Herpoel, Adèle
Passante, Lara
Schiffmann, Serge N
Gaillard, Afsaneh
Vanderhaeghen, Pierre # ×
Issue Date: Sep-2008
Publisher: Nature Publishing Group
Series Title: Nature vol:455 issue:7211 pages:351-357
Article number: 10.1038/nature07287
Abstract: The cerebral cortex develops through the coordinated generation of dozens of neuronal subtypes, but the mechanisms involved remain unclear. Here we show that mouse embryonic stem cells, cultured without any morphogen but in the presence of a sonic hedgehog inhibitor, recapitulate in vitro the major milestones of cortical development, leading to the sequential generation of a diverse repertoire of neurons that display most salient features of genuine cortical pyramidal neurons. When grafted into the cerebral cortex, these neurons develop patterns of axonal projections corresponding to a wide range of cortical layers, but also to highly specific cortical areas, in particular visual and limbic areas, thereby demonstrating that the identity of a cortical area can be specified without any influence from the brain. The discovery of intrinsic corticogenesis sheds new light on the mechanisms of neuronal specification, and opens new avenues for the modelling and treatment of brain diseases.
URI: 
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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