Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1
Hick, Anne-Christine * van Eyll, Jonathan M * Cordi, Sabine Forez, Céline Passante, Lara Kohara, Hiroshi Nagasawa, Takashi Vanderhaeghen, Pierre Courtoy, Pierre J Rousseau, Guy G Lemaigre, Frédéric P Pierreux, Christophe E # ×
BMC Developmental Biology vol:9
The exocrine pancreas is composed of a branched network of ducts connected to acini. They are lined by a monolayered epithelium that derives from the endoderm and is surrounded by mesoderm-derived mesenchyme. The morphogenic mechanisms by which the ductal network is established as well as the signaling pathways involved in this process are poorly understood.