Title: Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma
Authors: Van Keer, Jan ×
Delforge, Michel
Dierickx, Daan
Peerlinck, Kathelijne
Lerut, Evelyne
Sprangers, Ben #
Issue Date: 2016
Publisher: Hindawi Publishing Corporation
Series Title: Case Reports in Hematology vol:2016
Article number: 10.1155/2016/6020691
Abstract: Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use of bortezomib in a 51-year-old man with IgG lambda MM. To our knowledge, this is the first biopsy-proven case. In addition, reexposure to bortezomib 18 months later was associated with recurrence of TMA. This supports a possible causal role of bortezomib. The exact mechanisms remain to be elucidated.
ISSN: 2090-6560
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Molecular and Vascular Biology
Laboratory of Experimental Hematology (+)
Stem Cell Biology and Embryology (+)
Laboratory of Experimental Transplantation
× corresponding author
# (joint) last author

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