Title: Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells
Authors: Defourny, Jean
Poirrier, Anne-Lise
Lallemend, François
Mateo Sánchez, Susana
Neef, Jakob
Vanderhaeghen, Pierre
Soriano, Eduardo
Peuckert, Christiane
Kullander, Klas
Fritzsch, Bernd
Nguyen, Laurent
Moonen, Gustave
Moser, Tobias
Malgrange, Brigitte # ×
Issue Date: 2013
Series Title: Nature Communications vol:4
Article number: 10.1038/ncomms2445
Abstract: Hearing requires an optimal afferent innervation of sensory hair cells by spiral ganglion neurons in the cochlea. Here we report that complementary expression of ephrin-A5 in hair cells and EphA4 receptor among spiral ganglion neuron populations controls the targeting of type I and type II afferent fibres to inner and outer hair cells, respectively. In the absence of ephrin-A5 or EphA4 forward signalling, a subset of type I projections aberrantly overshoot the inner hair cell layer and invade the outer hair cell area. Lack of type I afferent synapses impairs neurotransmission from inner hair cells to the auditory nerve. By contrast, radial shift of type I projections coincides with a gain of presynaptic ribbons that could enhance the afferent signalling from outer hair cells. Ephexin-1, cofilin and myosin light chain kinase act downstream of EphA4 to induce type I spiral ganglion neuron growth cone collapse. Our findings constitute the first identification of an Eph/ephrin-mediated mutual repulsion mechanism responsible for specific sorting of auditory projections in the cochlea.
ISSN: 2041-1723
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Defourny et al_Nat Comm 2013.pdf Published 3994KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science