Title: Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration
Authors: Dimidschstein, Jordane
Passante, Lara
Dufour, Audrey
van den Ameele, Jelle
Tiberi, Luca
Hrechdakian, Tatyana
Adams, Ralf
Klein, Rüdiger
Lie, Dieter Chichung
Jossin, Yves
Vanderhaeghen, Pierre # ×
Issue Date: Sep-2013
Publisher: Cell Press
Series Title: Neuron vol:79 issue:6
Article number: 10.1016/j.neuron.2013.07.015
Abstract: Neurons of the cerebral cortex are organized in layers and columns. Unlike laminar patterning, the mechanisms underlying columnar organization remain largely unexplored. Here, we show that ephrin-B1 plays a key role in this process through the control of nonradial steps of migration of pyramidal neurons. In vivo gain of function of ephrin-B1 resulted in a reduction of tangential motility of pyramidal neurons, leading to abnormal neuronal clustering. Conversely, following genetic disruption of ephrin-B1, cortical neurons displayed a wider lateral dispersion, resulting in enlarged ontogenic columns. Dynamic analyses revealed that ephrin-B1 controls the lateral spread of pyramidal neurons by limiting neurite extension and tangential migration during the multipolar phase. Furthermore, we identified P-Rex1, a guanine-exchange factor for Rac3, as a downstream ephrin-B1 effector required to control migration during the multipolar phase. Our results demonstrate that ephrin-B1 inhibits nonradial migration of pyramidal neurons, thereby controlling the pattern of cortical columns.
ISSN: 0896-6273
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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