Title: Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders
Authors: Brennand, Kristen J ×
Marchetto, M Carol
Benvenisty, Nissim
Brüstle, Oliver
Ebert, Allison
Izpisua Belmonte, Juan Carlos
Kaykas, Ajamete
Lancaster, Madeline A
Livesey, Frederick J
McConnell, Michael J
McKay, Ronald D
Morrow, Eric M
Muotri, Alysson R
Panchision, David M
Rubin, Lee L
Sawa, Akira
Soldner, Frank
Song, Hongjun
Studer, Lorenz
Temple, Sally
Vaccarino, Flora M
Wu, Jun
Vanderhaeghen, Pierre
Gage, Fred H
Jaenisch, Rudolf #
Issue Date: Dec-2015
Publisher: Cell Press
Series Title: Stem Cell Reports vol:5 issue:6
Article number: 10.1016/j.stemcr.2015.10.011
Abstract: As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.
ISSN: 2213-6711
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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