Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders
Brennand, Kristen J × Marchetto, M Carol Benvenisty, Nissim Brüstle, Oliver Ebert, Allison Izpisua Belmonte, Juan Carlos Kaykas, Ajamete Lancaster, Madeline A Livesey, Frederick J McConnell, Michael J McKay, Ronald D Morrow, Eric M Muotri, Alysson R Panchision, David M Rubin, Lee L Sawa, Akira Soldner, Frank Song, Hongjun Studer, Lorenz Temple, Sally Vaccarino, Flora M Wu, Jun Vanderhaeghen, Pierre Gage, Fred H Jaenisch, Rudolf #
Stem Cell Reports vol:5 issue:6
As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.