Title: Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition
Authors: Shah, Disha ×
Praet, Jelle
Latif Hernandez, Amira
Höfling, Corinna
Anckaerts, Cynthia
Bard, Frédérique
Morawski, Markus
Detrez, Jan R
Prinsen, Els
Villa, Alessandro
De Vos, Winnok H
Maggi, Adriana
D'Hooge, Rudi
Balschun, Detlef
Rossner, Steffen
Verhoye, Marleen
Van der Linden, Annemie #
Issue Date: Sep-2016
Publisher: Elsevier
Series Title: Alzheimer's & Dementia vol:12 issue:9
Article number: 10.1016/j.jalz.2016.03.010
Abstract: In Alzheimer's disease (AD), pathologic amyloid-beta (Aβ) is synaptotoxic and impairs neuronal function at the microscale, influencing brain networks at the macroscale before Aβ deposition. The latter can be detected noninvasively, in vivo, using resting-state functional MRI (rsfMRI), a technique used to assess brain functional connectivity (FC).
ISSN: 1552-5260
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
× corresponding author
# (joint) last author

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