Title: Renal Nerve Stimulation-Induced Blood Pressure Changes Predict Ambulatory Blood Pressure Response After Renal Denervation
Authors: de Jong, Mark R
Adiyaman, Ahmet
Gal, Pim
Smit, Jaap Jan J
Delnoy, Peter Paul H M
Heeg, Jan-Evert
van Hasselt, Boudewijn A A M
Lau, Elizabeth O Y
Persu, Alexandre
Staessen, Jan A
Ramdat Misier, Anand R
Steinberg, Jonathan S
Elvan, Arif # ×
Issue Date: Sep-2016
Publisher: Lippincott Williams & Wilkins
Series Title: Hypertension vol:68 issue:3 pages:707-714
Article number: 10.1161/HYPERTENSIONAHA.116.07492
Abstract: Blood pressure (BP) response to renal denervation (RDN) is highly variable and its effectiveness debated. A procedural end point for RDN may improve consistency of response. The objective of the current analysis was to look for the association between renal nerve stimulation (RNS)-induced BP increase before and after RDN and changes in ambulatory BP monitoring (ABPM) after RDN. Fourteen patients with drug-resistant hypertension referred for RDN were included. RNS was performed under general anesthesia at 4 sites in the right and left renal arteries, both before and immediately after RDN. RNS-induced BP changes were monitored and correlated to changes in ambulatory BP at a follow-up of 3 to 6 months after RDN. RNS resulted in a systolic BP increase of 50±27 mm Hg before RDN and systolic BP increase of 13±16 mm Hg after RDN (P<0.001). Average systolic ABPM was 153±11 mm Hg before RDN and decreased to 137±10 mm Hg at 3- to 6-month follow-up (P=0.003). Changes in RNS-induced BP increase before versus immediately after RDN and changes in ABPM before versus 3 to 6 months after RDN were correlated, both for systolic BP (R=0.77, P=0.001) and diastolic BP (R=0.79, P=0.001). RNS-induced maximum BP increase before RDN had a correlation of R=0.61 (P=0.020) for systolic and R=0.71 (P=0.004) for diastolic ABPM changes. RNS-induced BP changes before versus after RDN were correlated with changes in 24-hour ABPM 3 to 6 months after RDN. RNS should be tested as an acute end point to assess the efficacy of RDN and predict BP response to RDN.
ISSN: 0194-911X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cardiovascular Sciences - miscellaneous
Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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