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Title: Carbohydrate and fatty acid perturbations in the amniotic fluid of the recipient twin of pregnancies complicated by twin-twin transfusion syndrome in relation to treatment and fetal cardiovascular risk
Authors: Dunn, Warwick B ×
Allwood, J William
Van Mieghem, Tim
Morris, R Katie
Mackie, Fiona L
Fox, Caroline E
Kilby, Mark D #
Issue Date: Aug-2016
Publisher: Elsevier
Series Title: Placenta vol:44 pages:6-12
Article number: 10.1016/j.placenta.2016.05.012
Abstract: Twin-twin transfusion syndrome (TTTS) complicates 15% of monochorionic twin pregnancies, often being associated with recipient cardiac dysfunction. Untreated, it has a fetal mortality rate of at least 90%; although treatment by fetoscopic laser coagulation significantly improves prognosis. Measurement of recipient amniotic fluid metabolites, such as cardiac Troponin T and atrial natriuretic polypeptide, correlate with cardiac function in this fetus. The aim of this study is to describe the amniotic fluid metabolomic profile in TTTS, relate this to fetal recipient cardiac function and assess the metabolomic changes induced by fetoscopic laser coagulation.
URI: 
ISSN: 0143-4004
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Organ Systems (+)
× corresponding author
# (joint) last author

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