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Title: Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study
Authors: Dixon, Suzanne C ×
Nagle, Christina M
Thrift, Aaron P
Pharoah, Paul D P
Pearce, Celeste Leigh
Zheng, Wei
Painter, Jodie N
Chenevix-Trench, Aocs Group Australian Cancer Study Ovarian Cancer Georgia
Fasching, Peter A
Beckmann, Matthias W
Lambrechts, Diether
Ziogas, Argyrios
Menon, Usha
Gayther, Simon A
Ramus, Susan J
Gentry-Maharaj, Aleksandra
Wu, Anna H
Pike, Malcolm C
Tseng, Chiu-Chen
Kupryjanczyk, Jolanta
Dansonka-Mieszkowska, Agnieszka
Vergote, Ignace
Budzilowska, Agnieszka
Spiewankiewicz, Beata
Webb, Penelope M #
Lambrechts, Sandrina
Van Nieuwenhuysen, Els
Rossing, Mary Anne
Doherty, Jennifer A
Wicklund, Kristine G
Chang-Claude, Jenny
Rudolph, Anja
Moysich, Kirsten B
Odunsi, Kunle
Goodman, Marc T
Wilkens, Lynne R
Thompson, Pamela J
Shvetsov, Yurii B
Dörk, Thilo
Park-Simon, Tjoung-Won
Hillemanns, Peter
Bogdanova, Natalia
Butzow, Ralf
Nevanlinna, Heli
Pelttari, Liisa M
Leminen, Arto
Modugno, Francesmary
Ness, Roberta B
Edwards, Robert P
Kelley, Joseph L
Heitz, Florian
Karlan, Beth Y
Kjær, Susanne K
Høgdall, Estrid
Jensen, Allan
Goode, Ellen L
Fridley, Brooke L
Cunningham, Julie M
Winham, Stacey J
Giles, Graham G
Bruinsma, Fiona
Milne, Roger L
Southey, Melissa C
Hildebrandt, Michelle A T
Wu, Xifeng
Lu, Karen H
Liang, Dong
Levine, Douglas A
Bisogna, Maria
Schildkraut, Joellen M
Berchuck, Andrew
Cramer, Daniel W
Terry, Kathryn L
Bandera, Elisa V
Olson, Sara H
Salvesen, Helga B
Thomsen, Liv Cecilie
Kopperud, Reidun K
Bjorge, Line
Kiemeney, Lambertus A
Massuger, Leon F A G
Pejovic, Tanja
Cook, Linda S
Le, Nhu D
Swenerton, Kenneth D
Brooks-Wilson, Angela
Kelemen, Linda E
Lubiński, Jan
Huzarski, Tomasz
Gronwald, Jacek
Menkiszak, Janusz
Wentzensen, Nicolas
Brinton, Louise
Yang, Hannah
Lissowska, Jolanta
Høgdall, Claus K
Lundvall, Lene
Song, Honglin
Tyrer, Jonathan P
Campbell, Ian
Eccles, Diana
Paul, James
Glasspool, Rosalind
Siddiqui, Nadeem
Whittemore, Alice S
Sieh, Weiva
McGuire, Valerie
Rothstein, Joseph H
Narod, Steven A
Phelan, Catherine
Risch, Harvey A
McLaughlin, John R
Anton-Culver, Hoda
Issue Date: Jun-2016
Publisher: Oxford University Press
Series Title: International Journal of Epidemiology vol:45 issue:3
Article number: dyw158
Abstract: Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents a causal effect, or holds for all histological subtypes. The lack of association observed for serous cancers may, for instance, be due to disease-associated weight loss. Mendelian randomization (MR) uses genetic markers as proxies for risk factors to overcome limitations of observational studies. We used MR to elucidate the relationship between BMI and ovarian cancer, hypothesizing that genetically predicted BMI would be associated with increased risk of non-high grade serous ovarian cancers (non-HGSC) but not HGSC.
URI: 
ISSN: 0300-5771
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Oncology - miscellaneous
Gynaecological Oncology
Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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