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Title: Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study
Authors: Overman, Margot ×
Pendleton, Neil
O'Neill, Terence W
Bartfai, Gyorgy
Casanueva, Felipe F
Finn, Joseph D
Forti, Gianni
Rastrelli, Giulia
Giwercman, Aleksander
Han, Thang S
Huhtaniemi, Ilpo T
Kula, Krzysztof
Lean, Michael E J
Punab, Margus
Lee, David M
Correa, Elon S
Ahern, Tomas
Verschueren, Sabine
Antonio, Leen
Gielen, Evelien
Rutter, Martin K
Vanderschueren, Dirk
Wu, Frederick C W
Tournoy, Jos #
Issue Date: 1-Jul-2016
Publisher: Steinkopff
Series Title: European Journal of Nutrition vol:Ahead of print
Abstract: PURPOSE:
Although lower levels of vitamin D have been related to poor cognitive functioning and dementia in older adults, evidence from longitudinal investigations is inconsistent. The objective of this study was to determine whether 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] levels are associated with specified measures of cognitive decline in ageing men.
METHODS:
The European Male Ageing Study (EMAS) followed 3369 men aged 40-79 over 4.4 years. 25(OH)D levels at baseline were measured by radioimmunoassay, and 1,25(OH)2D levels were obtained with liquid chromatography-tandem mass spectrometry. Visuoconstructional abilities, visual memory, and processing speed at baseline and follow-up were assessed using the Rey-Osterrieth Complex Figure Test (ROCF), Camden Topographical Recognition Memory (CTRM), and the Digit Symbol Substitution Test (DSST).
RESULTS:
Following attritions, a total of 2430 men with a mean (SD) age of 59.0 (10.6) were included in the analyses. At baseline, the mean 25(OH)D concentration was 64.6 (31.5) nmol/l, and mean 1,25(OH)2D level was 59.6 (16.6) pmol/l. In age-adjusted linear regression models, high 25(OH)D concentrations were associated with a smaller decline in the DSST (β = 0.007, p = 0.020). Men with low 25(OH)D levels (<50 nmol/l) showed a greater decline in the CTRM compared to men with higher (≥75 nmol/l) levels (β = -0.41, p = 0.035). However, these associations disappeared after adjusting for confounders such as depressive symptoms, BMI, and comorbidities. There was no indication of a relationship between 1,25(OH)2D and decline in cognitive subdomains.
CONCLUSION:
We found no evidence for an independent association between 25(OH)D or 1,25(OH)2D levels and visuoconstructional abilities, visual memory, or processing speed over on average 4.4 years in this sample of middle-aged and elderly European men.
URI: 
ISSN: 1436-6207
Publication status: accepted
KU Leuven publication type: IT
Appears in Collections:Gerontology and Geriatrics
Research Group for Musculoskeletal Rehabilitation
Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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