Title: Towards antiviral therapies for treating dengue virus infections
Authors: Kaptein, Suzanne JF ×
Neyts, Johan #
Issue Date: Oct-2016
Publisher: Elsevier Science Ltd.
Series Title: Current Opinion in Pharmacology vol:30 pages:1-7
Article number: S1471-4892(16)30050-9
Abstract: Dengue virus is an emerging human pathogen that poses a huge public health burden by infecting annually about 390 million individuals of which a quarter report with clinical manifestations. Although progress has been made in understanding dengue pathogenesis, a licensed vaccine or antiviral therapy against this virus is still lacking. Treatment of patients is confined to symptomatic alleviation and supportive care. The development of dengue therapeutics thus remains of utmost importance. This review focuses on the few molecules that were evaluated in dengue virus-infected patients: balapiravir, chloroquine, lovastatin, prednisolone and celgosivir. The lessons learned from these clinical trials can be very helpful for the design of future trials for the next generation of dengue virus inhibitors.
ISSN: 1471-4892
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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