Title: Lessons learned: HIV points the way towards precision treatment of mixed-lineage leukemia
Authors: Cermakova, Katerina ×
Weydert, Caroline
Christ, Frauke
De Rijck, Jan
Debyser, Zeger #
Issue Date: Aug-2016
Publisher: Elsevier Publications
Series Title: Trends in Pharmacological Sciences vol:37 issue:8 pages:660-671
Article number: S0165-6147(16)30036-0
Abstract: Protein-protein interactions are involved in most if not all pathogenic and pathophysiological processes and represent attractive therapeutic targets. Extensive biological and clinical research efforts have led to the identification and validation of several cellular hubs that are crucially involved in disease pathogenesis. An interesting example of such a hub is the lens epithelium-derived growth factor (LEDGF/p75), a protein that tethers multiple unrelated proteins and protein complexes to the chromatin. Its chromatin-tethering ability is linked to at least two unrelated diseases-HIV infection and MLL-rearranged acute leukemia. In this review we discuss recent progress in our understanding of the interaction of LEDGF/p75 with its binding partners and focus on the first steps towards therapies targeting protein-protein interactions of LEDGF/p75.
ISSN: 0165-6147
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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