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Title: Preclinical evaluation of a P2X7 receptor selective radiotracer: PET studies in a rat model with local overexpression of the human P2X7 receptor and in non-human primates
Authors: Ory, Dieter × Celen, Sofie Gijsbers, Rik Van den Haute, Chris Postnov, Andrey Koole, Michel Vandeputte, Caroline Andrés, José-Ignacio De Angelis, Meri Langlois, Xavier Bhattacharya, Anindya Schmidt, Mark Alcazar, Jesus Vanduffel, Wim Letavic, Michael A Van Laere, Koen Verbruggen, Alfons Debyser, Zeger Bormans, Guy #
Issue Date: May-2016
Publisher: Society of Nuclear Medicine
Series Title: Journal of Nuclear Medicine vol:Ahead of print
Article number: jnumed.115.169995
Abstract: The P2X7 receptor (P2X7R) orchestrates (neuro)inflammation and this is the basis for an increased interest in the development of antagonists inhibiting P2X7R function in the brain. This study provides the preclinical evaluation of (11)C-JNJ-54173717, a PET tracer for the P2X7R receptor in both rats and non-human primates.
Publication status: published
KU Leuven publication type: IT
Appears in Collections: Molecular Virology and Gene Therapy Radiopharmacy Research Group for Neurobiology and Gene Therapy Nuclear Medicine & Molecular Imaging Laboratory for Neuro- and Psychofysiology
× corresponding author
# (joint) last author
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