Title: Preclinical evaluation of a P2X7 receptor selective radiotracer: PET studies in a rat model with local overexpression of the human P2X7 receptor and in non-human primates
Authors: Ory, Dieter ×
Celen, Sofie
Gijsbers, Rik
Van den Haute, Chris
Postnov, Andrey
Koole, Michel
Vandeputte, Caroline
Andrés, José-Ignacio
De Angelis, Meri
Langlois, Xavier
Bhattacharya, Anindya
Schmidt, Mark
Alcazar, Jesus
Vanduffel, Wim
Letavic, Michael A
Van Laere, Koen
Verbruggen, Alfons
Debyser, Zeger
Bormans, Guy #
Issue Date: May-2016
Publisher: Society of Nuclear Medicine
Series Title: Journal of Nuclear Medicine vol:Ahead of print
Article number: jnumed.115.169995
Abstract: The P2X7 receptor (P2X7R) orchestrates (neuro)inflammation and this is the basis for an increased interest in the development of antagonists inhibiting P2X7R function in the brain. This study provides the preclinical evaluation of (11)C-JNJ-54173717, a PET tracer for the P2X7R receptor in both rats and non-human primates.
ISSN: 0161-5505
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Virology and Gene Therapy
Research Group for Neurobiology and Gene Therapy
Nuclear Medicine & Molecular Imaging
Laboratory for Neuro- and Psychofysiology
× corresponding author
# (joint) last author

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