Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women

Mehta, Divya; Tropf, Felix C; Gratten, Jacob; Bakshi, Andrew; Zhu, Zhihong; Bacanu, Silviu-Alin; Hemani, Gibran; Magnusson, Patrik KE; Barban, Nicola; Esko, Tõnu; Metspalu, Andres; Snieder, Harold; Mowry, Bryan J; Kendler, Kenneth S; Yang, Jian; Visscher, Peter M; McGrath, John J; Mills, Melinda C; Wray, Naomi R; Lee, S Hong; Schizophrenia Working Group of the Psychiatric Genomics Consortium,; Andreassen, Ole A; Bramon, Elvira; Bruggeman, Richard; Buxbaum, Joseph D; Cairns, Murray J; Cantor, Rita M; Cloninger, C Robert; Cohen, David; Crespo-Facorro, Benedicto; Darvasi, Ariel; DeLisi, Lynn E; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Escott-Price, Valentina; Freimer, Nelson B; Georgieva, Lyudmila; de Haan, Lieuwe; Henskens, Frans A; Joa, Inge; Julià, Antonio; Khrunin, Andrey; Lerer, Bernard; Limborska, Svetlana; Loughland, Carmel M; Macek, Milan; Magnusson, Patrik KE; Marsal, Sara; McCarley, Robert W; McIntosh, Andrew M; McQuillin, Andrew; Melegh, Bela; Michie, Patricia T; Morris, Derek W; Murphy, Kieran C; Myin-Germeys, Inez; Olincy, Ann; Van Os, Jim; Pantelis, Christos; Posthuma, Danielle; Quested, Digby; Schall, Ulrich; Scott, Rodney J; Seidman, Larry J; Toncheva, Draga; Tooney, Paul A; Waddington, John; Weinberger, Daniel R; Weiser, Mark; Wu, Jing Qin

doi:10.1001/jamapsychiatry.2016.0129

Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women

Author:

Mehta, Divya

Tropf, Felix C ; Gratten, Jacob ; Bakshi, Andrew ; Zhu, Zhihong ; Bacanu, Silviu-Alin ; Hemani, Gibran ; Magnusson, Patrik KE ; Barban, Nicola ; Esko, Tõnu ; Metspalu, Andres ; Snieder, Harold ; Mowry, Bryan J ; Kendler, Kenneth S ; Yang, Jian ; Visscher, Peter M ; McGrath, John J ; Mills, Melinda C ; Wray, Naomi R ; Lee, S Hong ; Schizophrenia Working Group of the Psychiatric Genomics Consortium, ; Andreassen, Ole A ; Bramon, Elvira ; Bruggeman, Richard ; Buxbaum, Joseph D ; Cairns, Murray J ; Cantor, Rita M ; Cloninger, C Robert ; Cohen, David ; Crespo-Facorro, Benedicto ; Darvasi, Ariel ; DeLisi, Lynn E ; Dinan, Timothy ; Djurovic, Srdjan ; Donohoe, Gary ; Drapeau, Elodie ; Escott-Price, Valentina ; Freimer, Nelson B ; Georgieva, Lyudmila ; de Haan, Lieuwe ; Henskens, Frans A ; Joa, Inge ; Julià, Antonio ; Khrunin, Andrey ; Lerer, Bernard ; Limborska, Svetlana ; Loughland, Carmel M ; Macek, Milan ; Magnusson, Patrik KE ; Marsal, Sara ; McCarley, Robert W ; McIntosh, Andrew M ; McQuillin, Andrew ; Melegh, Bela ; Michie, Patricia T ; Morris, Derek W ; Murphy, Kieran C ; Myin-Germeys, Inez ; Olincy, Ann ; Van Os, Jim ; Pantelis, Christos ; Posthuma, Danielle ; Quested, Digby ; Schall, Ulrich ; Scott, Rodney J ; Seidman, Larry J ; Toncheva, Draga ; Tooney, Paul A ; Waddington, John ; Weinberger, Daniel R ; Weiser, Mark ; Wu, Jing Qin

Keywords:

Science & Technology, Life Sciences & Biomedicine, Psychiatry, DE-NOVO MUTATIONS, PATERNAL AGE, PSYCHIATRIC-DISORDERS, BIPOLAR DISORDER, RISK, PSYCHOSIS, Adult, Alleles, Birth Order, Cohort Studies, Denmark, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Maternal Age, Phenotype, Pregnancy, Risk, Schizophrenia, Schizophrenia Working Group of the Psychiatric Genomics Consortium, LifeLines Cohort Study, and TwinsUK, 1199 Other Medical and Health Sciences, 1701 Psychology, 1702 Cognitive Sciences, 3202 Clinical sciences, 5203 Clinical and health psychology

Abstract:

A recently published study of national data by McGrath et al in 2014 showed increased risk of schizophrenia (SCZ) in offspring associated with both early and delayed parental age, consistent with a U-shaped relationship. However, it remains unclear if the risk to the child is due to psychosocial factors associated with parental age or if those at higher risk for SCZ tend to have children at an earlier or later age.