Title: The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia
Authors: Kurland, David B ×
Gerzanich, Volodymyr
Karimy, Jason K
Woo, Seung Kyoon
Vennekens, Rudi
Freichel, Marc
Nilius, Bernd
Bryan, Joseph
Simard, J Marc #
Issue Date: 2016
Publisher: BioMed Central
Series Title: Journal of Neuroinflammation vol:13 issue:1
Article number: 10.1186/s12974-016-0599-2
Abstract: Harmful effects of activated microglia are due, in part, to the formation of peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) synthase (NOS2). Because NOS2 expression is determined by Ca(2+)-sensitive calcineurin (CN) dephosphorylating nuclear factor of activated T cells (NFAT), and because Sur1-Trpm4 channels are crucial for regulating Ca(2+) influx, we hypothesized that, in activated microglia, Sur1-Trpm4 channels play a central role in regulating CN/NFAT and downstream target genes such as Nos2.
ISSN: 1742-2094
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cellular and Molecular Medicine - miscellaneous
Laboratory of Ion Channel Research
× corresponding author
# (joint) last author

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