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Title: Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation
Authors: Levine, Deborah J ×
Glanville, Allan R
Aboyoun, Christina
Belperio, John
Benden, Christian
Berry, Gerald J
Hachem, Ramsey
Hayes, Don
Neil, Desley
Reinsmoen, Nancy L
Snyder, Laurie D
Sweet, Stuart
Tyan, Dolly
Verleden, Geert
Westall, Glen
Yusen, Roger D
Zamora, Martin
Zeevi, Adriana #
Issue Date: Apr-2016
Publisher: Mosby-Year Book
Series Title: Journal of Heart and Lung Transplantation vol:35 issue:4 pages:397-406
Article number: 10.1016/j.healun.2016.01.1223
Abstract: Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid-organ transplant recipients, there are no standardized diagnostic criteria or an agreed-upon definition. Hence, a working group was created by the International Society for Heart and Lung Transplantation with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed toward donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or sub-clinical (normal allograft function). This consensus definition will have clinical, therapeutic and research implications.
URI: 
ISSN: 1053-2498
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
× corresponding author
# (joint) last author

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