Title: Technology in Parkinson's disease: Challenges and opportunities
Authors: Espay, Alberto J ×
Bonato, Paolo
Nahab, Fatta B
Maetzler, Walter
Dean, John M
Klucken, Jochen
Eskofier, Bjoern M
Merola, Aristide
Horak, Fay
Lang, Anthony E
Reilmann, Ralf
Giuffrida, Joe
Nieuwboer, Alice
Horne, Malcolm
Little, Max A
Litvan, Irene
Simuni, Tanya
Dorsey, E Ray
Burack, Michelle A
Kubota, Ken
Kamondi, Anita
Godinho, Catarina
Daneault, Jean-Francois
Mitsi, Georgia
Krinke, Lothar
Hausdorff, Jeffery M
Bloem, Bastiaan R
Papapetropoulos, Spyros #
Issue Date: Sep-2016
Publisher: John Wiley & Sons
Series Title: Movement Disorders vol:31 issue:9
Article number: 10.1002/mds.26642
Abstract: The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the "big data" acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. © 2016 International Parkinson and Movement Disorder Society.
ISSN: 0885-3185
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group for Neuromotor Rehabilitation
× corresponding author
# (joint) last author

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