Title: Metabolism, Protein Binding, and Renal Clearance of Microbiota-Derived p-Cresol in Patients with CKD
Authors: Poesen, Ruben ×
Evenepoel, Pieter
de Loor, Henriette
Kuypers, Dirk
Augustijns, Patrick
Meijers, Björn #
Issue Date: Jul-2016
Publisher: American Society of Nephrology
Series Title: Clinical Journal of the American Society of Nephrology vol:11 issue:7
Article number: CJN.00160116
Abstract: Colonic microbial metabolism substantially contributes to uremic retention solutes in CKD. p-Cresyl sulfate is the main representative of this group of solutes, relating to adverse outcomes. Other than sulfate conjugation, p-cresol is subjected to endogenous glucuronide conjugation. Whether the balance between sulfate and glucuronide conjugation is relevant in CKD is unexplored.
ISSN: 1555-9041
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Nephrology
Drug Delivery and Disposition
× corresponding author
# (joint) last author

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