Title: Lentiviral nuclear import: a complex interplay between virus and host
Authors: De Rijck, Jan ×
Vandekerckhove, Linos
Christ, Frauke
Debyser, Zeger #
Issue Date: May-2007
Publisher: Co. of Biologists
Series Title: BioEssays vol:29 issue:5 pages:441-451
Abstract: Although the capacity to infect non-dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal-facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host. BioEssays 29:441-451, 2007. (c) 2007 Wiley Periodicals, Inc.
ISSN: 0265-9247
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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