Title: Anti-HIV activity of N-1-adamantyl-4-aminophthalimide
Authors: Van Derpoorten, K ×
Balzarini, Jan
De Clercq, Erik
Poupaert, J H #
Issue Date: 1997
Series Title: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie vol:51 issue:10 pages:464-8
Abstract: The discovery of new leads acting via novel modes of action in the treatment of the human immunodeficiency virus (HIV), the causative agent of AIDS, remains a challenge. Along this line we synthesized and evaluated a series of N-substituted 4-aminophthalimides which were designed according to the models of thalidomide, phenytoin (PHT) and ameltolide. From a series of 24 compounds only N-1-adamantyl-4-aminophthalimide was endowed with anti-HIV-1 and -HIV-2 activity in CEM cell cultures.
ISSN: 0753-3322
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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