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Title: Past, present and future of dynamic kidney and liver preservation and resuscitation
Authors: Jochmans, Ina ×
Akhtar, M Zeeshan
Nasralla, David
Kocabayoglu, Peri
Boffa, Catherine
Kaisar, Maria
Brat, Aukje
O'Callaghan, John
Pengel, Liset H M
Knight, Simon
Ploeg, Rutger #
Issue Date: Sep-2016
Publisher: Munksgaard International Publishers
Series Title: American Journal of Transplantation vol:16 issue:9
Article number: 10.1111/ajt.13778
Abstract: The increased demand for organs has led to the increased usage of "higher-risk" kidney and liver grafts. These grafts from donation after circulatory death or expanded criteria donors are more susceptible to preservation injury and have a higher risk of unfavourable outcomes. Dynamic, instead of static preservation could allow for organ optimisation, offering a platform for viability assessment, active organ repair and resuscitation. Ex situ machine perfusion and in situ regional perfusion in the donor are emerging as potential tools to preserve and resuscitate vulnerable grafts. Preclinical findings have ignited clinical organ preservation research that investigates dynamic preservation, its various modes (continuous, pre-implantation) and temperatures (hypothermic, sub-, or normothermic). This review outlines the current status of dynamic preservation of kidney and liver grafts and describes on-going research and emerging clinical trials. This article is protected by copyright. All rights reserved.
URI: 
ISSN: 1600-6135
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Abdominal Transplantation
× corresponding author
# (joint) last author

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