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Title: Vitamin K dependent protection of renal function in multi-ethnic population studies
Authors: Wei, Fangfei
Drummen, Nadja E.A.
Schutte, Aletta E.
Thijs, Lutgarde
Jacobs, Lotte
Petit, Thibaut
Yang, Wenyi
Smith, Wayne
Zhang, Zhenyu
Gu, Yu-Mei
Kuznetsova, Tatiana
Verhamme, Peter
Allegaert, Karel
Schutte, Rudolph
Lerut, Evelyne
Evenpoel, Pieter
Vermeer, Cees
Staessen, Jan A # ×
Issue Date: 23-Jan-2016
Publisher: Elsevier
Series Title: EBioMedicine vol:4 pages:162-169
Abstract: Background: Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but
its role in preserving renal function remains unknown.
Methods: In 1166white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated
estimated glomerular filtration (eGFR [CKD-EPI formula]) and stage of chronic kidney disease (CKD
[KDOQI stages 2–3]) with inactive desphospho-uncarboxylated MGP (dp-ucMGP), using multivariable linear
and logistic regression.
Results: Among Flemish and white and black Africans, between-group differences in eGFR (90, 100 and
122 mL/min/1.73 m2), dp-ucMGP (3.7, 6.5 and 3.2 μg/L), and CKD prevalence (53.5, 28.7 and 10.5%)
were significant, but associations of eGFR with dp-ucMGP did not differ among ethnicities (P ≥ 0.075).
For a doubling of dp-ucMGP, eGFR decreased by 1.5 (P = 0.023), 1.0 (P = 0.56), 2.8 (P = 0.0012)
and 2.1 (P b 0.0001) mL/min/1.73 m2 in Flemish, white Africans, black Africans and all participants combined;
the odds ratios for moving up one CKD stage were 1.17 (P = 0.033), 1.03 (P = 0.87), 1.29 (P = 0.12) and 1.17
(P = 0.011), respectively.
Interpretation: In the general population, eGFR decreases and CKD risk increaseswith higher dp-ucMGP, a marker
of VK deficiency. These findings highlight the possibility that VK supplementation might promote renal health.
© 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
ISSN: 2352-3964
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cardiovascular Sciences - miscellaneous
Hypertension and Cardiovascular Epidemiology
Molecular and Vascular Biology
Organ Systems (+)
Faculty of health and social work - UC Leuven
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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