Title: Enhanced performance for the analysis of prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry using a new atmospheric pressure ionization source
Authors: Lubin, Arnaud ×
Geerinckx, Suzy
Bajic, Steve
Cabooter, Deirdre
Augustijns, Patrick
Cuyckens, Filip
Vreeken, Rob J #
Issue Date: Apr-2016
Publisher: Elsevier
Series Title: Journal of Chromatography A vol:1440 pages:260-5
Article number: S0021-9673(16)30171-6
Abstract: Eicosanoids, including prostaglandins and thromboxanes are lipid mediators synthetized from polyunsaturated fatty acids. They play an important role in cell signaling and are often reported as inflammatory markers. LC-MS/MS is the technique of choice for the analysis of these compounds, often in combination with advanced sample preparation techniques. Here we report a head to head comparison between an electrospray ionization source (ESI) and a new atmospheric pressure ionization source (UniSpray). The performance of both interfaces was evaluated in various matrices such as human plasma, pig colon and mouse colon. The UniSpray source shows an increase in method sensitivity up to a factor 5. Equivalent to better linearity and repeatability on various matrices as well as an increase in signal intensity were observed in comparison to ESI.
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Pharmaceutical Analysis
× corresponding author
# (joint) last author

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