Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke
Hernández-Jiménez, Macarena × Martínez-López, Diego Gabandé-Rodríguez, Enrique Martín-Segura, Adrian Lizasoain, Ignacio Ledesma, María D Dotti, Carlos Moro, María A #
Lippincott Williams & Wilkins
Stroke vol:47 issue:1 pages:206-13
3β-Hydroxysteroid-Δ24 reductase (DHCR24) or selective alzheimer disease indicator 1 (seladin-1), an enzyme of cholesterol biosynthetic pathway, has been implicated in neuroprotection, oxidative stress, and inflammation. However, its role in ischemic stroke remains unexplored. The aim of this study was to characterize the effect of seladin-1/DHCR24 using an experimental stroke model in mice.