Title: The role of TRPM4 in cardiac contractility and arrhythmias
Other Titles: De rol van TRPm4 in cardiale contractiliteit en aritmieën.
Authors: Jacobs, Griet
Issue Date: 11-Mar-2016
Abstract: TRPM4 is a Ca2+-activated non-selective cation channel that belongs to the family of the Transient Receptor Potential (TRP) ion channels. TRPM4 is a monovalent-selective cation channel, which is activated by an increase of the intracellular Ca2+ concentration. Trpm4 is highly expressed in the heart and was recently suggested as a novel regulator of ventricular contractility. Additionally, it was hypothesized before that TRPM4-like channels might play a role in the development of Ca2+-dependent triggered arrhythmias. Therefore, we investigated the role of TRPM4 in cardiac contractility and arrhythmias in living animals.
Publication status: published
KU Leuven publication type: TH
Appears in Collections:Laboratory of Ion Channel Research (VIB-KU Leuven Center for Brain & Disease Research)
Physiology Section (-)

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