Title: Dehydroepiandrosterone (DHEA) inhibits voltage-gated T-type calcium channels
Authors: Chevalier, M
Gilbert, Guillaume
Lory, P
Marthan, R
Quignard, J F ×
Savineau, J P #
Issue Date: Jun-2012
Publisher: Elsevier
Series Title: Biochemical Pharmacology vol:83 issue:11 pages:1530-9
Article number: 10.1016/j.bcp.2012.02.025
Abstract: Dehydroepiandrosterone (DHEA) and its sulfated form, DHEAS, are the most abundant steroid hormones in the mammalian blood flow. DHEA may have beneficial effects in various pathophysiological conditions such as cardiovascular diseases or deterioration of the sense of well-being. However to date, the cellular mechanism underlying DHEA action remains elusive and may involve ion channel modulation. In this study, we have characterized the effect of DHEA on T-type voltage-activated calcium channels (T-channels), which are involved in several cardiovascular and neuronal diseases.
ISSN: 0006-2952
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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