Imbalances between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in maternal serum during preterm labor
Tency, Inge × Verstraelen, Hans Kroes, Ivo Holtappels, Gabriële Verhasselt, Bruno Vaneechoutte, Mario Verhelst, Rita Temmerman, Marleen #
Public Library of Sciene
PLoS One vol:7 issue:11 pages:e49042
Matrix metalloproteinases (MMPs) are involved in remodeling of the extracellular matrix (ECM) during pregnancy and parturition. Aberrant ECM degradation by MMPs or an imbalance between MMPs and their tissue inhibitors (TIMPs) have been implicated in the pathogenesis of preterm labor, however few studies have investigated MMPs or TIMPs in maternal serum. Therefore, the purpose of this study was to determine serum concentrations of MMP-3, MMP-9 and all four TIMPs as well as MMP:TIMP ratios during term and preterm labor.